Welcome at www pages of Electrophysiological lab, Dept. of Pathophysiology,
Charles Univ. - Faculty of Medicine, Hradec Králové, Czech Republic,
founded in 1956 by Prof. J. Peregrin († 2002).
Our research activities have been recently oriented mainly to analysis of visual information processing in man with the use of visual evoked potentials (VEPs). In the last years we try to contribute to the development of a new variant of VEPs related to motion-onset (M-VEPs), since they represent quite specific activity of the magnocellular system and the dorsal stream of the visual pathway. A set of our clinical pilot studies (in Publications) suggests that the M-VEPs can extend diagnostic applications and sensitivity of VEP examination.
Currently we have been also studying visual cognitive processes through evaluation of event related potentials (P300 wave) or mismatch negativity. Simultaneous recordings of VEPs from primary (striate), secondary (associate mediotemporal) and cognitive (centroparietal) areas of the brain cortex enable quite complex assessment of visual system dysfunctions in large spectrum of neuro-ophthalmological and neuro-psychiatric disorders (see our pilot studies in Publications).